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Cells in the HG condition were cultured in the medium containing 35 mM of D-glucose (Sigma-Aldrich), and cells in the SG condition were cultured in DMEM/F12 (this represents control, CTR, condition)

10.1155/2013/974313 27 CittadiniA.NapoliR.MontiM

JVIM, 26(2):30410

It has been well established that pro-inflammatory cytokines produced by the adipose tissue in obesity affect normal nutrition-related signalling, establishing the progression to MetS and ultimately to T2D [125]